Wellness
People frequently come in to see me with vexing problems that cause them to be miserable, and cause me to scratch my head wondering what could be going on. I continue to read a lot of journals, listen to many webinars and podcasts, and go to conferences to expand my knowledge. I contract with some specialty labs to be able to offer tests that are not commonly available in other offices. I am finding many of these specialized tests are quite helpful for my patients.
For those of you worried about heart disease, diabetes, and obesity, we run specialized testing to look at your risk and to find the best treatments. Specialized blood tests through labs like Cleveland Heart Lab, can give us more information to tease out if your high cholesterol is a problem, or if you have a problem even if your cholesterol is low. We can look at several different inflammatory markers, how your individual genetics impact your risk, and how well your body is processing sugars. We can order a CAC (coronary calcium screening), a specialized type of CT scan, to see how likely you are to have stroke or heart attack in the near future. We were one of the first practices in the area that offered a test called Cleerly, a CT angiogram which is further analyzed to tell us how much soft and hard plaque is present. This is a breakthrough in cardiovascular disease management.
When it comes to prevention & treatment of a heart attack or stroke, we can discuss not only which medications may help, but also other means such as diet and exercise. There is a wealth of information out there on what types of diets are best for preventing not only heart attacks and stroke, but also diabetes, cancer, and autoimmune disorders. Currently, we don't have good studies proving certain foods can prevent cancer etc, but we are starting to get some good ideas of what a good, healthy, preventative diet looks like. I especially enjoy working with patients eating a low carb, ancestral (paleo or primal) diet and who are interested in fasting.
I see many patients who feel sick and tired. For those, we start with basic testing, but conventional treatment with medications is often not successful. Treatment may include supplements, but also discussions about sleep, stress reduction, meditation, specific exercises and even the presence and types of light in your environment. Of course, diet plays an important role in this also.
Since most supplements sold in the US do not contain what they claim, it is essential to know which supplements to buy. Check out my Supplements Facts page for more information.
This is just a smattering of the options available to you here at my office. If you suffer from, or are worried about any of these issues, give us a call.
What is Paleo/Primal?
and Why to Go to a Doctor that Understands It
Ancestral (Paleo and Primal) lifestyles refer to living like our ancestors did. This does not mean you need to rent a cave to live in and wear animal skins! We as a species have spent many thousands of generations becoming optimized to certain foods and activities. We have now drifted away from them, to the detriment of our health. Let me explain.
Humans have been around for about 2 1/2 million years. For most of that time we were nomads, following our food supply. For the most part, we ate a lot of hoofed animals, along with plant material. We know this by looking at fossilized poop (among other things) and by accounts given by explorers that came in contact with hunter-gatherer tribes over the past several hundred years. We appeared to be pretty healthy, were tall and strong, but also probably pretty lazy, and only spent a few hours a day hunting, gathering, and sheltering. Our life expectancy was not very high, but that's because we had a high infant mortality rate and also had a higher rate of dying from infections (no antibiotics or vaccines) and trauma. But if we lived past those issues, we were generally very healthy into our old age, and had a similar life expectancy to what we have now. BTW - some of this information was extrapolated from knowledge of the health of hunter gatherer tribes which still existed 100 years ago.
Starting about 10,000 years ago, we began settling down, domesticating animals for food and growing crops. We consumed more calories, and began reproducing at a higher rate. But we also started developing diseases of the modern age, such as heart disease, cancer, osteoporosis, autoimmune disorders, even things like appendicitis, gall bladder disease and acne!
Today, when we have epidemics of obesity, diabetes, heart disease, and cancer, many people are looking at where we went wrong, and what we can do to fix it. With all of modern medicine, what have we accomplished? Our infant mortality rate is much lower, and we survive trauma much better. We also don't die of complications from urinary tract infections, strep throat or polio (at least not often). But aside from that, we are not living any longer, and we are often wracked with pain and disability as we age.
What is so different about how we live now?
A very important elements is diet. Ancient man (and woman) rarely ate grains, legumes or dairy. Potatoes were inedible, and sugar did not exist. The tribe would take down an animal, maybe a mastodon or a rhino or a pig, and eat the entire thing raw. The meat itself would have been lean, but they would have eaten all the organs including the marrow, making the entire meal fairly high in fat. We would have eaten our fill, then when we got hungry again, we'd take down another animal. (Not six small meals a day!)
Edible vegetation would have been less available. Those that tasted good (like fruits) would have been smaller and less sweet than we have now, and also only ripe and available for a very short period during the year. Many vegetables would have been bitter and/or toxic. Also, we would not have hunted a mastodon and milked it, and even if we'd found some milk, we would have lost our ability to process milk sugars once we were past weaning age for human milk (generally age 3-6 years).
Our diet would have consisted mostly of animal products along with vegetables and fruits when they were ripe and roots (tubers). We probably did a fair amount of walking and ran only when we were running after prey, or away from predators. We lifted and squatted and threw things. We tended to sleep when it got dark and slept until our body was fully rested. We had access to lots of sunlight during the day, We had intense episodes of stress (like when we were chased by predators) but less of the chronic episodes of stress of modern life. We ate less frequently and had periods of fasting when we did not have access to food. And we were apparently quite healthy.
For young people, trying to follow an ancestral lifestyle should hopefully give them a long healthy life. Using modern medicine judiciously should help assure they don't succumb to their ancestors' nemeses of infection, trauma or early death in childbirth.
Unfortunately for those of us who are little older, we may need a little more help. Because we often have done irreparable damage (through misguided advice we may have followed so far), diet and general lifestyle changes may not be enough. We may need some help from modern medicine to keep us healthy and prevent premature death. But we also don't want to be over treated, and to inadvertently make us worse off by taking medications, which are too aggressive and cause adverse effects.
So, why would you want to see a physician that understands ancestral lifestyles?
There is a fine line between too much and too little medical care. I try to balance that fine line, looking at the risk vs. benefit ratio for each intervention I do with my patients, taking into account ancestral principals. You don't need antibiotics every time you get a cold, but it would be stupid not to treat a significant infection with antibiotics and die of sepsis. Not everyone needs medication for their cholesterol, but there are clearly people alive today who would be dead if they hadn't been on those medications.
My job is to work with you by advising you which interventions are most beneficial to you. We do that by discussing the risks and benefits of each therapy. Some aspects of an ancestral lifestyle conflict with recommended guidelines. As a physician with over 3 decades of experience, I've learned what tends to work and what doesn't, and we can decide together to achieve meaningful goals.
I do specialized testing (like the Advanced Lipid testing and CAC for heart disease) so we can get a better idea of what your risk really is, before I recommend a treatment. I listen to you, so we can try to fit any treatment recommendations into your lifestyle. And most importantly, I follow many of the same recommendations I give you, so I know what is involved.
The goal I have for all my patients is to live a healthy long life, requiring as few medical interventions (including pills) as possible. If that is also your goal, then we should talk.
Offering Advanced Lipid Blood Testing
We are pleased to announce we offer personalized medicine and wellness recommendations in conjunction with Cleveland Heart Lab.
80% of people with coronary artery (heart) disease have normal cholesterol levels. Despite "adequate" control on medication, many people still have heart attacks and strokes. Obviously, today's routine cholesterol tests are failing to identify the majority of people who are at risk for heart attacks. The limited focus of these tests on "good" and "bad" cholesterol is simply not good enough to accurately identify those most at risk. So, how can you protect yourself?
Cholesterol guidelines are made by committees, and therefore are compromises. They also lag years behind the research, and have to take into account the cost of implementing them for the entire population. However, some people would like more information to enable them to make informed decisions about their health. Advanced lipid testing are comprehensive blood tests that are based on current research targeting vascular disease risks such as heart attacks, strokes, and diabetes. It allows us to personalize treatment plans based on family history, the size of cholesterol particles, and the level of arterial inflammation. It also allows us to predict likely reactions to different medications, foods, alcohol, stress, and exercise.
What does Advanced Lipid testing include?
An evaluation would be based on a panel of specific test of your blood sample. All of these tests help assess risk for vascular disease (heart attack, stroke, diabetes). A typical evaluation would include:
Routine lipid panel, including total cholesterol, LDL, HDL, TG
LDL particle size
HDL particle size
Apo A and HDL particle number
Apo B -and LDL particle number
sdLDL (small dense) and OxLDL (oxidized) LDL levels
Lp(a) - high levels can cause blood to clot too easily, inherited, can alter with medications
Homocysteine
Vascular inflammatory markers such as Lp-PLA2 and Myeloperoxidase
Highly Sensitive CRP - measures inflammation
Fibrinogen - another measure of inflammation
NT-proBNP - measure of cardiac stress
Omega 3:6 fatty acids profile
Diabetes Tests
Glycemic control - how well glucose is controlled on a short and long term basis
Insulin resistance - fasting insulin levels, and how well the body is utilizing insulin by looking at leptin and others.
Who would be a good candidate for this test?
Anyone who has any of the following risk factors:
Heart disease
Diabetes
Abnormal cholesterol levels (High LDL, Triglycerides or low HDL)
High blood pressure
Obesity
Cigarette smoker
Family history of heart disease, diabetes, or kidney disease
How much does it cost, and what do I need to do?
Insurance generally covers most of the cost. Depending on your insurance, we can often give you a good idea if you will have any out of pocket expense, and how much. Out of pocket expenses are eligible for reimbursement by medical spending accounts.
You will need to fast for 12-14 hours for the test and usually the blood can be drawn at the time of your appointment. The results will take 3-4 weeks to come back.
What then?
Dr. Moghissi will review your results with you in detail, and make recommendations for possible treatment. These recommendations may include medication, dietary changes, exercise and/or stress reduction. We may want to do additional testing and/or follow up testing in several months to see how you respond to the treatment.
Weight Loss
Most of my patients are either trying to lose weight, improve their cholesterol, and/or trying to live a healthier lifestyle with a better diet. For the past 35 years I have tried all sorts of things to help them, and rarely have we had long term success. We have tried various diets, pills (phen-fen being a spectacular failure), injections (GLP’s) and surgery. None have consistently given significant long term success, including the popular GLP meds.
The Mechanics of Weight Loss
Since for most of human existence our problem has been too little food, the body aggressively guards its fat stores. Therefore, when the body is deprived of energy it will preferentially break down lean body mass (i.e. muscle) and try to leave the fat stores intact. When weight is gained back, it will be gained preferentially as fat. That is one of the reasons why yoyo dieting is so bad. After a few cycles of dieting you may weigh the same, but your body composition will be different as you will generally have much more fat compared to muscle than you had before. To make things even worse, there is evidence that your basal metabolic rate (the minimum amount of energy you need, AKA resting rate) can be permanently lowered after losing large amounts of weight. This makes it even more important to do this carefully!
How can you lose fat preferentially? One way to do this is by eating lots of protein. Protein protects the muscle, and is a natural appetite suppressant. In addition, exercise especially with resistance training will help preserve muscle mass. A low carb or keto diet typically has lots of protein, and people who follow this do lose weight, and their cholesterol will often get better, even though that diet is very high in fat. The problem is that many people find it difficult to follow that diet long term.
But we also need fiber and the other good things (bioactive food components like antioxidants and phytochemicals) we get from vegetables. Most importantly, they fuel the microbiome and provide important micronutrients we can't get from other sources. What we don't really need are starches (but they taste so good….)! There is one other consideration. Most tissues of the body require a continuous supply of protein and amino acids, and muscle is the only reservoir. When we eat protein, it goes to replenish that muscle that has been broken down since the last time we ate some protein. Too much protein, however, appears to be just wasted, it gets broken down and converted to glucose (raising out blood sugar)
The Ideal Diet
What are we looking for in a diet? We want a decent amount of (but not too much) protein, decent amounts of vegetable, not too much fruit, and minimal amounts of starch. This diet should be low in energy (calories), but individualized for each person. We should be looking towards losing fat, not pounds. It needs to be easy to follow, and not too expensive. It needs to be safe for everyone, especially diabetics, patients with heart disease, patients who have had weight loss surgery, children, elderly, and women who may become pregnant while on the program. It should have a maintenance program that can be followed once the dieter has reached their goal. And the program should be with real food, so the dieter can learn to eat correctly for the rest of his life.
The mechanics of this is something we can discuss during an office visit.